PhD student: Cancer associated fibroblast autophagy, metabolism and desmoplasia in colorectal cancer
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The Institute of Tissue Medicine and Pathology (ITMP) is an institution of the University of Bern, Switzerland with three major tasks: teaching, research and diagnostic service. In total, there are around 190 employees at the Institute. The ITMP provides an attractive setting to perform cutting-edge translational research in direct collaboration with pathologists and oncologists treating patients.
We are excited to present a unique opportunity to join an interdisciplinary team (spatial biology and ECM: Hannah Williams, metabolism: Martin Sadowski, and autophagy: Mario Tschan, cancer research teams further supported by GI pathologists: Heather Dawson, Rina Mehmeti) to examine the role of cancer associated fibroblast autophagy for desmoplasia in colorectal cancer (CRC).
Desmoplasia is a common feature of tumour biology and defined by the excessive deposition of extracellular matrix (ECM) components such as collagen. A prominent desmoplastic reaction has been associated with tumour aggressiveness and inhibiting drug delivery across several cancer types. Understanding the biology underpinning desmoplasia and thereby identifying novel therapeutic targets, represents a relevant clinical challenge. Emerging evidence from breast cancer suggests a role for CAF autophagy and altered metabolism in the induction and maintenance of the desmoplastic reaction. Whether this applied to other cancer types such as CRC remains to be elucidated.
In consideration of this we are looking for an enthusiastic and ambitious PhD candidate with an interest in oncology and the tumour microenvironment to examine the role of CAF autophagy and altered metabolism on desmoplasia and tumour behaviour in CRC. The successful candidate will explore this through a variety of in vitro methods across 2D and 3D mono- and co- culture models utilising clinically relevant patient derived specimens. As part of our interdisciplinary team, you will receive a comprehensive training from expertise in autophagy, spatial biology and ECM, metabolism, spatial biology and clinical pathology.
Requirements
We are looking for a candidate with an academic degree (MSc or equivalent) in life sciences or biomedical sciences acceptable for matriculation at a Swiss University (Bologna compatible). Previous technical experience with 2D cell culture models and routine cell and molecular biology techniques is essential. The candidate should be proactive, collaborative, have excellent communication skills and possess an aptitude to work in a team as a well as the initiative to work independently. Prior expertise in programming languages (R, Python) or bioinformatics is an advantage. Fluency in English is a prerequisite. The successful applicant will be enrolled in the Graduate School for Cellular and Biomedical Sciences, University of Bern (
www.gcb.unibe.ch).
Application
Please send your CV including a list of publications and description of your professional experience, a short motivational letter with statement of your research interests, a list of 2 references (including contact information) and copies of University diploma transcripts with grades as a
single PDF-document by email to Cornelia Mileto (
cornelia.mileto@unibe.ch). We will continue to accept applications until a suitable candidate is found.
Duration of appointment: 3-4 years
Start: January 2026 or by arrangement
Salary: According to Swiss National science Foundation (
www.snf.ch)
